Claudia Schmauss, MD
Associate Professor of Psychiatry
Vice Chair, Institutional Animal Care and Use Committee at Columbia University
We are interested in unraveling molecular mechanisms underlying gene expression changes in psychopathological states.
The main focus of our research is on the role of gene x environment interaction in modulating adult behavioral phenotypes. We are conducting molecular, anatomic, and behavioral studies on animal models of depression-like behaviors and animal models of cognitive dysfunctions to study the role of epigenetic changes in gene expression in psychopathological states.
- Models of Psychiatric Disorders
- Cognitive/Systems Neuroscience
Projects on various mouse models aim at addressing:
1. Epigenetic modulation of antidepressant efficacy
2. Transgenerational effects of early life stress
3. Epigenetic regulation of RNA processing in brain
Schmauss, C. (2015). An HDAC-dependent epigenetic mechanism that enhances the efficacy of the antidepressant drug fluoxetine. Sci. Rep. 5, 8171; DPI:10.1038/srep08171.
Schmauss, C., Lee-McDermott, Z., and Ramos Medina, L. (2014). Trans-generational effects of early life stress: The role of maternal behavior. Sci. Rep. 4, 4873; DOI:10.1038/srep04873.
Zimnisky, R., Chang, G., Gyertyán, I., Kiss, B., Adham, N., and Schmauss, C. (2013). Carprazine, a dopamine D3-receptor-preferring partial agonist, blocks PCP-induced impairment of working memory, attention set-shifting, and recognition memory in the mouse. Psychopharmacol. 226: 91-100.
Levine, A., Worrell, T.R., Zimnisky, R., and Schmauss, C. (2012). Early life stress triggers sustained changes in histone deacetylase expression and histone H4 modifications that alter responsiveness to adolescent antidepressant treatment. Neurobiol. Dis. 45: 488-498.
Mehta, M. and Schmauss, C. (2011). Strain-specific cognitive deficits in adult mice exposed to early life stress. Behav. Neurosci. 125: 29-36.
Navailles, S., Zimnisky, R., and Schmauss, C. (2010). Expression of glucocorticoid receptor and early growth response gene 1 during postnatal development of two inbred strains of mice exposed to early life stress. Dev. Neurosci. 32: 139-148.
Schmauss, C., Zimnisky, R., Mehta, M, and Shapiro L.P. (2010). The roles of phospholipase C activation and alternative ADAR1 and ADAR2 pre-mRNA splicing in modulating serotonin 2C-receptor editing in vivo. RNA 16: 1779-1785.