John J. Mariani, MD
Associate Professor of Clinical Psychiatry
Director, Substance Treatment and Research Service
Dr. John Mariani is an Associate Professor of Clinical Psychiatry at the College of Physicians and Surgeons of Columbia University and a Research Psychiatrist at the New York State Psychiatric Institute. After receiving his medical degree from the New York University School of Medicine and completing his psychiatry residency at the Beth Israel Medical Center in New York City, where he served as Chief Resident, Dr. Mariani began a two-year addiction psychiatry research fellowship at Columbia University. In 2005, he joined the faculty of the Division on Substance Abuse as a Research Psychiatrist. Under the mentorship of Dr. Frances Levin, he has remained active in clinical research and is the recipient of a K-23 Mentored Patient-Oriented Research Career Development Award from the National Institute on Drug Abuse. Currently, Dr. Mariani is the Director of Columbia University’s Substance Treatment and Research Service (STARS). His research has primarily focused on investigating novel pharmacotherapies for addictive disorders.
Development of novel pharmacotherapies for substance use disorders.
Dr. Mariani is the principal investigator (PI) of a NIDA-funded R01,"Quetiapine Pharmacotherapy for Cannabis Dependence". The goal of this double-blind study is to study the effects of quetiapine on cannabis dependence, the hypothesis being that the sedating, appetite stimulating and anxiolytic effects of quetiapine will reduce cannabis withdrawal symptoms. Dr. Mariani is also the principal investigator of NIAAA-funded R21 AA017691, "Gabapentin for Abstinence Initiation in Alcohol Dependence". The goal of this double-blind pilot project is to study the effects of gabapentin treatment of alcohol dependence in an abstinence-initiation model, where participants are actively using alcohol at study entry, and the change in use pattern from baseline is measured throughout the study period.