Jared Van Snellenberg
Assistant Professor of Clinical Psychology (in Psychiatry)
Research Scientist (Level V) at Division of Translational Imaging, New York State Psychiatric Institute
Broadly speaking, my research focuses on how the brain instantiates our internal mental experiences. More specifically, I am interested in how disruptions in brain signalling, at both the molecular and network levels of analysis, can lead to the perceptual and cognitive disruptions observed in psychotic disorders and other psychiatric conditions, as well as how these signalling systems, and dynamic interactions between brain networks, give raise to human cognitive capabilities such as learning and memory.
In pursuit of these interest, I carry out functional Magnetic Resonance Imaging studies of healthy individuals and patients with psychosis, both during a resting state and while performing memory or learning tasks. I also have a strong commitment to innovative methods development, and the use of meta-analytic methods to summarize research findings in the literature.
Girgis, R. R., Van Snellenberg, J. X., Glass, A., Kegeles, L. S., Thompson, J. L., Wall, M., Cho, R. Y., Carter, C. S., Slifstein, M., Abi-Dargham, A., & Lieberman, J. A. (in press). A proof of concept, randomized controlled trial of DAR-0100A, a dopamine-1 receptor agonist, for cognitive enhancement in schizophrenia. Journal of Psychopharmacology.
Van Snellenberg, J. X., Slifstein, M., Read, C., Weber, J., Thompson, J. L., Wager, T. D., Shohamy, D., Abi-Dargham, A., & Smith, E. E. (2015). Dynamic shifts in brain network activation during supracapacity working memory task performance. Human Brain Mapping, 36, 1245-1264.
Slifstein, M.1, van de Giessen, E.1, Van Snellenberg, J., Thompson, J. L., Narendran, R., Gil, R., Hackett, E., Girgis, R., Ojeil, N., Moore, H., D’Souza, D., Malison, R. T., Huang, Y., Lim, K-P., Nabulsi, N., Carson, R. E., Lieberman, J. A., & Abi-Dargham, A. (2015). Deficits in prefrontal cortical and extra-striatal dopamine release in schizophrenia: A PET fMRI study. JAMA Psychiatry, 72, 316-324. 1These authors contributed equally to this work.
Van Snellenberg, J. X., Conway, A. R. A., Spicer, J., Read, C., & Smith, E. E. (2014). Capacity estimates in working memory: Reliability and interrelationships among tasks. Cognitive, Affective, and Behavioral Neuroscience, 14, 106-116.
Anticevic, A.1, Van Snellenberg, J. X.1, Cohen, R. E., Repovs, G., Dowd, E. C., & Barch, D. M. (2012). Amygdala recruitment in schizophrenia in response to aversive emotional material: A meta-analysis of neuroimaging studies. Schizophrenia Bulletin, 38, 608-621. 1These authors contributed equally to this work.
Metcalfe, J., Van Snellenberg, J. X., DeRosse, P., Balsam, P., & Malhotra, A. (2012). Judgment of agency in schizophrenia: An impairment in autonoetic metacognition. Philosophical Transactions of the Royal Society B: Biological Sciences, 367, 1391-1400.
Van Snellenberg, J. X., & de Candia, T. (2009). Meta-analytic evidence for familial coaggregation of schizophrenia and bipolar disorder. Archives of General Psychiatry, 66, 748-755.
Van Snellenberg, J. X. (2009). Working memory and long-term memory deficits in schizophrenia: Is there a common substrate? Psychiatry Research: Neuroimaging, 174, 89-96.
Wager, T. D., Lindquist, M. A., Nichols, T. E., Kober, H., & Van Snellenberg, J. X. (2009). Evaluating the consistency and specificity of neuroimaging data using meta-analysis. NeuroImage, 45, S210-S221.
Van Snellenberg, J. X., & Wager, T. D. (2009). Cognitive and motivational functions of the human prefrontal cortex. In A.-L. Christensen, D. Bougakov, & E. Goldberg (Eds), Luria’s Legacy in the 21st Century (pp. 30-61). New York: Oxford University Press.
Van Snellenberg, J. X., Torres, I. J., & Thornton, A. E. (2006). Functional Neuroimaging of Working Memory in Schizophrenia: Task Performance as a Moderating Variable. Neuropsychology, 20, 497-510.