Michael E. Goldberg, MD
David Mahoney Professor of Brain and Behavior (in Neuroscience and Neurology [in Psychiatry and Ophthalmology])
Director, Mahoney Center
Herbert Pardes Building of the New York State Psychiatric Institute
1051 Riverside Drive
Unit 87 New York, NY 10032
Public Transportation: Yes
Disabled Access: Yes
We study the psychophysics and physiology of cognitive processes in the monkey, using single unit recording, iontophoresis, and careful behavioral measurements. The thrust of the lab has been understanding the physiology of visual attention - how the brain selects important objects in the visual field for further processing - and the generation of spatially accurate behavior despite a constantly moving eye. Current projects include studying the role of somatosensory cortex in the eye-position modulation of visual responses in parietal cortex; studying a newly discovered untuned cholinergic modulatory signal in the monkey parietal cortex that predicts how well the monkey will perform on the current trial of a difficult task, correlates inversely with the monkey's recent history of success or failure, and correlates positively with the neuron's response to a visual transient; studying the involuntarily establish of spatial memory memory in the lateral intraparietal area and the parahippocampal gyrus, studying the fine structure of perisaccadic remapping of visual receptive fields, and studying the role of the cerebellum in visualmotor associations. Recent discoveries in the laboratory include the demonstration of a predictive relationship of parietal activity to both saccadic reaction time and visual attention; the demonstration that the lateral parietal area acts as a linear summing junction for at least three independent signals: a saccadic signal, and undifferentiated visual signal, and a cognitive signal, and the proprioceptive representation of eye position in monkey area 3a of primary somatosensory cortex, and the time course of eye-position modulation of visual responses in the parietal cortex..
Graduate Seminar in Systems Neuroscience
Lectures in the Basic and Clinical Neuroscience Course
Section teaching in Clinical Correlates of Basic Neuroscience
Resident and student teaching on the CUMC neurology hospitalist service
1. Duhamel, J.-R., Colby, C.L., and Goldberg, M.E. The updating of the representation of visual space in parietal cortex by intended eye movements. Science, 255: 90-92, 1992.
2. Gottlieb, J., Kusunoki, M., and Goldberg, M.E. The representation of visual salience in monkey parietal cortex Nature 391: 481-484, 1998.
3. Hasegawa, R.P., Blitz, A.M., Geller, N. and Goldberg, M.E. Neurons in monkey prefrontal cortex that track past or predict future performance. Science 290:1786-9, 2000.
4. Bisley, JW and Goldberg, M.E. Neuronal Activity in LIP and Spatial Attention. Science, 299:81-86, 2003.
5. Ipata AE, Gee AL, Goldberg, ME and Bisley, JW. Activity in the lateral intraparietal area predicts the goal and latency of saccades in a free viewing visual search task. J. Neurosci. 26: 3656-61, 2006.
6. Ipata AE, Gee AL, Bisley, JW and Goldberg, ME. Responses in the lateral intraparietal area to a popout stimulus are reduced if it is overtly ignored. Nat. Neurosci. 9:171-6, 2007.
7. Wang, X, Zhang,M, Cohen, IS, and Goldberg,ME. The proprioceptive representation of eye position in monkey primary somatosensory cortex, Nat. Neuroscience, 10:, 640-646, 2007.
8. Ganguli S, Bisley JW, Roitman j, Shalden M, Goldberg ME, Miller K . . One dimensional dynamics of attention and decision making in LIP. Neuron, 58:15-25, 2008.
9. Gee, A. L., A. E. Ipata, et al. "Neural enhancement and pre-emptive perception: the genesis of attention and the attentional maintenance of the cortical salience map." Perception 37(3): 389-400, 2008.
10. Ipata, A. E., A. L. Gee, et al. "Neurons in the lateral intraparietal area create a priority map by the combination of disparate signals." Exp Brain Res. 171: 37-45, 2009.
11. Bisley JW, Goldberg ME. Attention, intention, and priority in the parietal lobe. Ann. Rev. Neurosci 33:1-21, 2010.
12. Falkner AE, Krishna BS, Goldberg ME. Surround suppression sharpens the priority map in LIP. J. Neurosci, 38:12787-97, 2010.
13. Gee AL, Ipata AE, Goldberg ME. Activity in V4 reflects the direction, but not the latency, of saccades during visual search. J Neurophysiol. 104: 2187-2193, 2010.
14. Xu Y, Wang X, Peck C, Goldberg, ME. The time course of the tonic oculomotor proprioceptive signal in area 3a of somatosensory cortex. J. Neurophysiology, 106:71-7, 2011.
15. Ipata, A., A. Gee, et al. "Feature attention evokes task-specific pattern selectivity in V4 neurons." Proceedings of the National Academy of Sciences of the United States of America 109(42): 16778-16785. PMID: 23043119, 2012.
16. Xu, B., C. Karachi, et al. "The postsaccadic unreliability of gain fields renders it unlikely that the motor system can use them to calculate target position in space." Neuron 76(6): 1201-1209. PMID- 23259954, 2012.
17. Falkner AL, Krisha BS, & Goldberg ME. Spatial Representation and Cognitive Modulation of Response Variability in the Lateral Intraparietal Area Priority Map. J Neurosci. 2013 Oct 9;33(41):16117-30, 2013.
18. Steenrod S, Phillips MH, & Goldberg ME. The lateral intraparietal area (LIP) codes the location of saccade targets and not the dimension of the saccades that will be made to acquire them. J Neurophysiol 109(10):2596-2605, 2013.
19. Zhang, M., X. Wang and M. E. Goldberg. "A spatially nonselective baseline signal in parietal cortex reflects the probability of a monkey's success on the current trial." Proc Natl Acad Sci USA 111(24): 8967-8972, 2014.
20. Krishna BS, Ipata AE, Bisley JW, Gottlieb J, Goldberg ME. Extrafoveal preview benefit during free-viewing visual search in the monkey. J Vis. 8:14(1). pii: 6. doi:10.1167/14.1.6, 2014.