Maria Karayiorgou, MD
Professor of Psychiatry at CUMC
Maria Karayiorgou, M.D., is a Professor of Psychiatry (in Genetics & Physiology) and Acting Chief of the Division of Medical Genetics in the Department of Psychiatry at Columbia University. Her intellectual interest in Psychiatry led her to medical school and clinical training in Psychiatry, as well as academic research in Psychiatric Genetics at the Massachusetts Institute of Technology, the Fred Hutchinson Center and the Rockefeller University. She came to Columbia University as a Professor in 2006.
Specialities: Rare genetic variants in schizophrenia etiology.
Dr. Karayiorgou's research program centers around the genetics of schizophrenia and aims to elucidate the genetic architecture of the disease, identify susceptibility genes for the disease, and use these findings to understand the underlying biology. To this end, she follows a number of complementary approaches designed to obtain convergent lines of evidence. Her approaches range from human genetic studies to animal model studies to clinical and translational neuroscience studies.
Landmark discoveries of Dr. Karayiorgou's research include the discovery of the importance of rare genetic variants in schizophrenia etiology, starting with an early publication that established a significant role in schizophrenia for a de novo CNV on 22q11.2 (Karayiorgou et al. PNAS 92, 7612-6, 1995) and culminating with recent whole exome sequencing studies (Xu et al. Nat Genet 44, 1365-9, 2012).