Nicole Schupf, PhD
Professor of Epidemiology (in the Gertrude H. Sergievsky Center, in the Taub Institute for Research on Alzheimer's Disease and the Aging Brain and in Psychiatry) at the Columbia University Medical Center
Dr. Schupf trained originally as a physiological psychologist, receiving her Ph.D. from New York University in 1970. She worked for several years on neuroimmunological mechanisms in lupus cerebritis. She then received her M.P.H. from the University of California in 1984 and a Dr.P.H. in Epidemiology from Columbia University in 1995. She is a Professor of Epidemiology at CUMC in the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Faculty of Medicine. Nicole Schupf conducts studies of aging and Alzheimer’s disease in adults with Down syndrome and in the general population.
A major focus of her current work is the investigation of genetic and nongenetic factors that influence risk or age at onset of Alzheimer's disease in individuals with Down syndrome and in a multi-ethnic Northern Manhattan cohort. She is particularly interested in women's health and the relation of menopause to cognitive decline and risk of Alzheimer's disease Current work includes studies of the contribution of polymorphisms in genes involved in estrogen biosynthesis and estrogen receptor activity to age at onset and risk of Alzheimer’s disease (AD) and studies of biomarkers for early detection of cognitive decline, particularly the role of abeta peptides as a risk biomarker for Alzheimer’s disease.